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JobsPennsylvaniaPhiladelphiaAssociate Vice President, Enterprise AI Architecture & Strategy

Associate Vice President, Enterprise AI Architecture & Strategy

Penn Medicine
AI GovernanceOn-siteFull-timePhiladelphia, PA

Penn Medicine is hiring for the role of Associate Vice President, Enterprise AI Architecture & Strategy, Philadelphia, PA (On-site). This is an AI Governance role in the governance, risk, and compliance field. Review the full details below and apply directly with Penn Medicine.

Organization: Penn MedicineLocation: Philadelphia, PAWorkplace: On-siteFocus: AI GovernancePosted: Aug 18, 2026
Penn Medicine is hiring for this AI Governance role in Philadelphia, one of the metros GRC Careers tracks for governance, risk, and compliance hiring. See other GRC roles in Philadelphia →

Reporting to the VP of Enterprise Technology Architecture and Strategy, the AVP defines, governs, and advances the organization's enterprise-wide AI and generative AI strategy and architecture within a complex, highly regulated healthcare environment. Serves as the enterprise leader for AI technology strategy, architecture, and governance, aligning AI vision, roadmap, standards, and operating model with organizational strategy across clinical care, research, academic, and operational domains, ensuring AI investments are clinically safe, ethically sound, secure, scalable, and compliant. Owns multi-year AI technology strategy and architecture roadmaps, reference architectures, and governance frameworks. Establishes enterprise standards for AI/ML and GenAI platforms, agentic AI orchestration, AI monitoring and observability, and LLM model lifecycle management (development, validation, deployment, monitoring, retirement), and integration with EHRs, clinical systems, and research platforms. Oversees AI and GenAI governance including architecture review, model risk management, clinical safety, and ethical AI. Partners with Information Security, Privacy, Legal, Compliance, Clinical Informatics, and Risk Management for HIPAA and AI-related regulatory compliance. Education and experience: Bachelor's degree required; 15+ years of IT experience with 7+ years of enterprise architecture leadership and 3+ years as an AI enterprise architect and strategist. AI governance or machine learning certification preferred.

Location and market context

This role is based in Philadelphia on-site. Local candidates benefit from being close to Penn Medicine's teams and regional hiring market. Confirm the exact in-office expectation and any relocation support with the employer.

About AI governance roles

AI governance sits at the intersection of policy, risk, and engineering. Teams are standing up model inventories, use-case intake and review, risk classification, and control monitoring as regulation and board scrutiny of AI intensify. Roles like this one are typically evaluated against frameworks such as NIST AI RMF, ISO/IEC 42001, the EU AI Act, and internal model-risk and privacy practices.

How to position yourself for this AI governance role

Strong candidates emphasize experience translating policy into operational controls, working across legal, compliance, security, product, and data teams, documenting AI system risks, and supporting governance processes. In your resume and outreach, tie your experience to how Penn Medicine would apply NIST AI RMF, ISO/IEC 42001, the EU AI Act, and internal model-risk and privacy practices, and lead with concrete outcomes rather than duties.

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